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Use the corresponding Set-ClusterResource command if required.
The web application configuration files have a 'MultiSubnetFailoverFlag' option that should also be set to true if multi-subnet AGs are used. See SynWeb - SQL Connection Pooling for details.
Other Considerations
Nodes should share the same hardware configuration, notably drive assignment. If synchronous commit is utilised then the server should have identical hardware for performance. Also need to consider network latency between cluster nodes and failover behaviour, in particular if setting synchronous commit with auto failover.
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